Thursday, June 14, 2012

Greyhound Chromatography confirms appointment as Authorised Sigma Aldrich dealer

Greyhound Chromatography and Allied chemicals are pleased to confirm their appointment as an authorised distributor for Sigma Aldrich. This appointment gives Greyhound Chromatography the exciting opportunity to supply over 300,000 products from Sigma Aldrich, Fluka Analytical, Supelco Analytical and Sigma Life Science.

For over 30 years Greyhound has been supplying high quality Chromatography consumables to laboratories around the world. The addition of Sigma Aldrich products to their portfolio increases an extensive range that covers all areas of Environmental, Petrochemical, Food, Forensics, Chemical and Pharmaceutical analysis. Greyhound holds stock of many popular products for prompt delivery via their extensive logistics network.

Greyhound prides itself on personal service which provides prompt, efficient, cost-effective, safe delivery of all products. Edit this text

With state-of-the art facilities and highly trained staff, Greyhound provides technical advice and distribution of Chromatography consumables across all disciplines. Greyhound’s service is designed to provide a wide range of products, to help our clients to achieve excellent, cost-effective results.

Sigma Aldrich’s products are an exciting addition to Greyhound’s portfolio of Chemical Standards; Chiral Chromatography; Derivatives Analysis; Solvents; Dioxins/Furans/PCBs/PBDEs; Environmental Analysis; Gas Filters; GC; GC-MS; LC-MS; HPLC; ICP, ICP-MS, AA; Ion Chromatography; Lamps; Prep Silica; Reagents; SPE Solid Phase Extraction; SPME Solid Phase Micro-Extraction; Syringes; TLC Thin Layer Chromatography; Valves; Vials/Caps/Septa.

Greyhound’s dedicated technical sales team is available to discuss your requirements in detail, from the application of products, to sourcing and prompt delivery. They can be contacted by phone 0151 649 4000 or email

About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High Technology company. Its biochemical and organic chemical products and kits are used in scientific research, including genomic and proteomic research, biotechnology, pharmaceutical development and as key components in pharmaceutical, diagnostic and other high technology manufacturing. Sigma-Aldrich has customers in life science companies, university and government institutions, hospitals, and in industry. Over one million scientists and technologists use its products. Sigma-Aldrich operates in 38 countries and has 7,700 employees providing excellent service worldwide. Sigma-Aldrich is committed to Accelerating Customer Success through Innovation and Leadership in Life Science, High Technology and Service. For more information about Sigma-Aldrich, please visit its award-winning website at

Further details available from Sue Baker, Marketing Manager, Greyhound Chromatography and Allied Chemicals, 6, Kelvin Park, Birkenhead, Merseyside, CH41 1LT. Tel: 0151 649 4000

Thursday, June 14, 2012

Pesticides and Herbicides a Growing Concern in the Global Food Supply Chain Greyhound Chromatography

Toxaphene, a complex organochlorine pesticide, has been the most broadly applied pesticide in the United States and other countries since the 1970s. The United States banned the use of this pesticide by 1990 after the toxicity and persistence of toxaphene became unquestionable. In 2002, the U.S. EPA was contacted regarding concerns about toxaphene residual wastes and degradation products into streams and estuaries. Traditional methods could potentially underestimate residues once the toxaphene weathering process had begun in the environment. Because of the potential for toxaphene underestimation, degradation products need to be determined with highly sensitive methods. These events have culminated in the validation of a suitable extraction method for weathered toxaphene and its degradation products in fish tissues using Accelerated Solvent Extraction.

Pesticide and Metabolite Certified eference Standards are available from Greyhound Chromatography and Allied Chemicals, distributors for Chem Service Inc
F106 Toxaphene (TM) 8001-35-2
PS-79 Camphechlor 8001-35-2
F106BJS Toxaphene (TM) Solution CAS Not Available
F106RPS Toxaphene (TM) Solution CAS Not Available
F106BRPS Toxaphene (TM) Solution CAS Not Available
F106JS Toxaphene (TM) Solution CAS Not Available
PP-7S Toxaphene & Chlordane CAS Not Available
PP-7N Toxaphene & Chlordane - Neat CAS Not Available
F106AS Toxaphene (TM) Solution CAS Not Available
F106AJS Toxaphene (TM) Solution CAS Not Available
F106S Toxaphene (TM) Solution CAS Not Available
F106BS Toxaphene (TM) Solution CAS Not Available
CTA608-1S Arochlors. Toxaphene & Chlordane Solutions Kit - 608 CAS Not Available

Thursday, June 14, 2012

Headspace Grade Solvents for Analysis of Organic Volatile Impurities Greyhound Chromatography

Organic Volatile Impurities (OVI) in pharmaceuticals, commonly referred to as residual solvents, are trace organic volatile chemicals used or produced in the manufacturing of active substances, excipients, or in the preparation of medicinal products.

Appropriate selection of the solvent for the synthesis of medicinal substance is usually a critical parameter in the synthetic process, as it may enhance the yield, or determin characteristics, such as purity, crystal form, dissolution and solubility. Unfortunately many of the solvents are not completely removed by practical manufacturing techniques; therefore, their content should be evaluated and justified.

The International Conference on Harmonisation (ICH) method Q3C, United States Pharmacopoeia (USP) Method 467, and the European Pharmocopeia (EP) method 2.4.24, have set guidelines to identify residual solvents in pharmaceuticals and ensure that these solvents are not above the concentration limits according to the risk they pose for human health. Revised procedures for the identification and quantification of OVI consist of a static headspace extraction coupled with Gas Chromatographic (GC) separation. Static headspace technique is a precise and well-accepted method for the analysis of residual solvents. This technique is used for concentrating residual solvents from the sample preparation into the gas phase, resulting in the improvement of their detection limits in the GC analysis. Samples analysed by this technique may need a suitable solvent for dissolution, and procedues for water-soluble and water-insoluble samples are described 1,2,3, in the full document. For water-soluble samples, use of Biosolve Headspace grade solvents: Dimethylacetamide (DMA), Dimethylformamide (DMF), Dimethylimidazolidinone (DMI) and Dimethylsulfoxide (DMSO) is described in the full document, but other high boiling solvents, such as N-Methyl-2-Pyrrolidone (NMP) have aslo been found to be suitable for Headspace analysis.

Since 2006, Biosolve optimised its headspace grade solvents for accurate analysis of residual solvents in medicinal products. The purity of the solvents specifically evaluated by ananlysis of the Headspace grade solvent against OVI standard solution to ensure the absence of interfering peaks in the GC chromatogram.

The full document demonstrates the compatibility of Biosolve Headspace grade solvents as well as their cleanliness for the analysis of OVI in the Headspace-GC- technique. To do just that Biosolve chose a variety of common process solvents, representing a wide range of elution by the GC analyses. Blanks of each Headspace solvent and OVI standard solutions were prepared by pipetting 1mL of the liquid in to 20mL Headspace vial. Final content of OVI in the standard solutions was calculated with 100mg of tested medicinal sample.

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