Phthalates are Linked to Incidence of Childhood Asthma | Chem Service Certified Reference Standards supplied by Greyhound Chromatography

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Phthalates are Linked to Incidence of Childhood Asthma


The number of children diagnosed with asthma continues to rise in the United States and scientists are exploring the links between the chronic respiratory disease and chemical compounds found in air pollution, tobacco smoke and other sources. One team of scientists from the Columbia Center for Children's Environmental Health at the Columbia University Mailman School of Public Health investigated the effects of prenatal exposure to two phthalates – butylbenzyl phthalate and di-n-butyl phthalate – as published in the journal Environmental Health Perspectives. They discovered these chemicals increased the overall risk of childhood asthma by more than 70 percent.

The results of this study may have an impact on public health efforts to control the incidence of childhood asthma.

'We have to protect pregnant women'
According to the Asthma and Allergy Foundation of America, the number of children ages 5 to 14 years diagnosed with asthma in the U.S. nearly doubled between 1980 and 1993. That figure continued to rise over the next two decades. As of 2011, more than 7 million American children younger than 18 years had asthma. During that same year, more than 4 million of these individuals experienced at least one asthma attack. This condition can make it difficult for children to engage in everyday activities, and in some cases may even prove fatal.

The authors of the new study had previously studied the impact of prenatal exposure to various chemical compounds on the incidence of childhood asthma. For the current research, they decided to focus on BBzP and DnBP. In an experiment, they followed 300 pregnant women and measured metabolism of four phthalates by analyzing urine samples. Urine was collected from the mothers in the third trimester of pregnancy, as well as from the children at ages 3, 5 and 7 years. The researchers then compared the incidence of asthma in the upper one-third of subjects based on phthalate exposure to that of the bottom one-third.

Results showed that BBzP raised the risk of childhood asthma by 72 percent between the top and bottom thirds of the study subjects. For DnBP, that risk increase was 78 percent.

"The fetus is extremely vulnerable during pregnancy. While it is incumbent on mothers to do everything they can to protect their child, they are virtually helpless when it comes to phthalates like BBzP and DnBP that are unavoidable. If we want to protect children, we have to protect pregnant women," said senior study author Rachel Miller, M.D.

The researchers were unable to discern the most prominent sources of phthalate exposure among the study subjects, but these compounds are found in a range of products, including plastic food containers, vinyl flooring, insect repellent, automobile steering wheels and dashboards, and shower curtains. While the scientists are not entirely clear on how phthalates can drive childhood asthma, they proposed that these chemical compounds may cause inflammation and oxidative stress in developing fetuses.

Previously, phthalates had been banned from various childhood products. No such measures have been taken for pregnant mothers.

Phthalates are a group of compounds that are primarily used as vinyl softeners. They provide flexibility and durability to plastics that are
used in many industrial and consumer products, including children’s toys, food packaging, medical devices, building materials and
personal care items.


Due to the high potential for exposure, these products are being monitored to determine the risk to humans and the environment.
Phthalates are classified as endocrine disruptors because of their ability to interfere with the body’s endocrine system and, possibly,
causing birth defects, developmental defects, and cancer.

Phthalate Standards available from Chem Service Inc
Chem Service offers an extensive line of phthalate standards and it is growing. If you do not see the compound you need, please contact
us and we may be able to produce it.

  • N-11179-10G Benzyl 2-ethylhexyl phthalate 10gm

    • NG-11186-10G Benzyl isohexyl phthalate 10gm
    • N-11216-10G Bis(2-ethoxyethyl)phthalate 605-54-9 10gm
    • N-11216-500MG Bis(2-ethoxyethyl)phthalate 605-54-9 500mg
    • N-11216-5G Bis(2-ethoxyethyl)phthalate 605-54-9 5gm
    • S-11216J4-1ML Bis(2-ethoxyethyl)phthalate Solution 1000ug/ml in Hexane 1mL
    • S-11216J4-5ML Bis(2-ethoxyethyl)phthalate Solution 1000ug/ml in Hexane 5mL
    • N-11223-10G Bis(2-ethylhexyl)hexahydro phthalate 10gm
    • N-11224-10G Bis(2-ethylhexyl)isophthalate 137-89-3 10gm
    • N-11226-10G Bis(2-ethylhexyl)phthalate 117-81-7 10gm
    • N-11226-1G Bis(2-ethylhexyl)phthalate 117-81-7 1gm
    • N-11226-5G Bis(2-ethylhexyl)phthalate 117-81-7 5gm
    • S-11226J1-1ML Bis(2-ethylhexyl)phthalate Solution 100ug/ml in Hexane 1mL
    • S-11226J1-5ML Bis(2-ethylhexyl)phthalate Solution 100ug/ml in Hexane 5mL
    • N-11304-10G Bis(2-methoxyethyl)phthalate 117-82-8 10gm
    • S-11304A5-1ML Bis(2-methoxyethyl)phthalate Solution 2000ug/ml in Acetonitrile 1mL
    • S-11304A5-5ML Bis(2-methoxyethyl)phthalate Solution 2000ug/ml in Acetonitrile 5mL
    • S-11304J4-1ML Bis(2-methoxyethyl)phthalate Solution 1000ug/ml in Hexane 1mL
    • S-11304J4-5ML Bis(2-methoxyethyl)phthalate Solution 1000ug/ml in Hexane 5mL
    • N-11305-1G Bis(2-n-butoxyethyl)phthalate 117-83-9 1gm
    • N-11305-5G Bis(2-n-butoxyethyl)phthalate 117-83-9 5gm
    • S-11305J4-1ML Bis(2-n-butoxyethyl)phthalate Solution 1000ug/ml in Hexane 1mL
    • S-11305J4-5ML Bis(2-n-butoxyethyl)phthalate Solution 1000ug/ml in Hexane 5mL
    • N-11309-10G Bis(4-methyl-2-pentyl)phthalate 146-50-9 10gm
    • N-11309-5G Bis(4-methyl-2-pentyl)phthalate 146-50-9 5gm
    • S-11309J4-1ML Bis(4-methyl-2-pentyl)phthalate Solution 1000ug/ml in Hexane 1mL
    • S-11309J4-5ML Bis(4-methyl-2-pentyl)phthalate Solution 1000ug/ml in Hexane 5mL
    • N-11304-500MG Bis(methoxyethyl)phthalate 117-82-8 500mg
    • N-11320-10G Bis[2-(2-ethoxyethoxy)ethyl]phthalate 117-85-1 10gm
    • N-11356-10G Butyl 2-ethylhexyl phthalate 85-69-8 10gm
    • N-11360-1G Butyl benzyl phthalate 85-68-7 1gm
    • N-11360-5G Butyl benzyl phthalate 85-68-7 5gm

    • S-11360J1-1ML Butyl benzyl phthalate Solution 100ug/ml in Hexane 1mL
    • S-11360J1-5ML Butyl benzyl phthalate Solution 100ug/ml in Hexane 5mL
    • N-11364-10G Butyl cyclohexyl phthalate 84-64-0 10gm
    • N-11382-10G Butyl decyl phthalate 89-19-0 10gm
    • N-11368-10G Butyl isodecyl phthalate 10gm
    • N-11374-10G Butyl octyl phthalate 84-78-6 10gm
    • NG-N70-1G Decamethylene diammonium terephthalate 1gm
    • N-11310-1G Di(methylcyclohexyl)phthalate 1gm
    • NG-11614-10G Dialkyl phthalate linear C7-C9-Cll 10gm
    • N-11617-10G Diallyl phthalate 131-17-9 10gm
    • NG-15921-2.5G Diallyl terephthalate 2.5gm
    • N-11620-500MG Diamyl phthalate 131-18-0 500mg
    • N-11620-5G Diamyl phthalate 131-18-0 5gm
    • S-11620B7-1ML Diamyl phthalate Solution 5000ug/ml in Acetone 1mL
    • S-11620B7-5ML Diamyl phthalate Solution 5000ug/ml in Acetone 5mL
    • N-11626-1G Dibenzyl phthalate 523-31-9 1gm
    • S-11626J1-1ML Dibenzyl phthalate Solution 100ug/ml in Hexane 1mL
    • S-11626J1-5ML Dibenzyl phthalate Solution 100ug/ml in Hexane 5mL
    • N-11589-1G Dibutyl phthalate 84-74-2 1gm
    • N-11684-10G Dicyclohexyl phthalate 84-61-7 10gm
    • N-11684-5G Dicyclohexyl phthalate 84-61-7 5gm
    • S-11684X5-1ML Dicyclohexyl phthalate Solution 2000ug/ml in Methylene chloride 1mL
    • S-11684X5-5ML Dicyclohexyl phthalate Solution 2000ug/ml in Methylene chloride 5mL
    • N-11704-10G Diethyl phthalate 84-66-2 10gm
    • N-11704-1G Diethyl phthalate 84-66-2 1gm
    • S-11704J1-1ML Diethyl phthalate Solution 100ug/ml in Hexane 1mL
    • S-11704J1-5ML Diethyl phthalate Solution 100ug/ml in Hexane 5mL
    • N-11710-1G Diethyl terephthalate 636-09-9 1gm
    • N-13834-1G Diheptyl phthalate (Mixture of branched chain isomers) 41451-28-9 1gm
    • N-13811-10G Diisoamyl phthalate 605-50-5 10gm
    • N-11728-5G Diisobutyl phthalate 84-69-5 5gm
    • S-11728B6-1ML Diisobutyl phthalate Solution 2500ug/ml in Acetone 1mL
    • S-11728B6-5ML Diisobutyl phthalate Solution 2500ug/ml in Acetone 5mL
    • N-11734-10G Diisodecyl phthalate 26761-40-0 10gm
    • N-11735-10G Diisohexyl phthalate 10gm
    • N-11737-1G Diisononyl phthalate 68515-48-0 1gm
    • NG-11742-10G Diisooctyl isophthalate 10gm
    • NG-11743-10G Diisooctyl phthalate 10gm
    • NG-11749-10G Diisotridecyl phthalate 27253-26-5 10gm
    • N-11765-10G Dimethyl iso-phthalate 1459-93-4 10gm
    • N-11765-5G Dimethyl iso-phthalate 1459-93-4 5gm
    • N-11770-10G Dimethyl phthalate 131-11-3 10gm
    • N-11770-1G Dimethyl phthalate 131-11-3 1gm
    • S-11770H1-1ML Dimethyl phthalate Solution 100ug/ml in Ethyl acetate 1mL
    • S-11770H1-5ML Dimethyl phthalate Solution 100ug/ml in Ethyl acetate 5mL
    • S-11770M1-1ML Dimethyl phthalate Solution 100ug/ml in Methanol 1mL
    • S-11770M1-5ML Dimethyl phthalate Solution 100ug/ml in Methanol 5mL
    • N-11773-10G Dimethyl terephthalate 120-61-6 10gm
    • N-11773-5G Dimethyl terephthalate 120-61-6 5gm
    • NG-16328-5G Dimethyl-4-hydroxy isophthalate 5985-24-0 5gm
    • NG-16347-5G Dimethyl-5-nitroisophthalate 13290-96-5 5gm

    • NG-16425-10G Dimethyl-5-sulfoisophthalate, sodium salt 3965-55-7 10gm
    • N-11589-10G Di-n-butyl phthalate 84-74-2 10gm
    • S-11589J1-1ML Di-n-butyl phthalate Solution 100ug/ml in Hexane 1mL
    • S-11589J1-5ML Di-n-butyl phthalate Solution 100ug/ml in Hexane 5mL
    • S-11589A1-1ML Di-n-butylphthalate Solution 100ug/ml in Acetonitrile 1mL
    • NG-11592-10G Di-n-decyl phthalate 84-77-5 10gm
    • N-11596-10G Di-n-hexyl phthalate 84-75-3 10gm
    • N-11596-5G Di-n-hexyl phthalate 84-75-3 5gm
    • S-11596J4-1ML Di-n-hexyl phthalate Solution 1000ug/ml in Hexane 1mL
    • S-11596J4-5ML Di-n-hexyl phthalate Solution 1000ug/ml in Hexane 5mL
    • N-11600-10G Di-n-octyl isophthalate 4654-18-6 10gm
    • N-11601-10G Di-n-octyl phthalate 117-84-0 10gm
    • N-11601-5G Di-n-octyl phthalate 117-84-0 5gm
    • S-11601J1-1ML Di-n-octyl phthalate Solution 100ug/ml in Hexane 1mL
    • N-11601-1G Di-n-octylphthalate 117-84-0 1gm
    • N-11785-10G Dinonyl phthalate 84-76-4 10gm
    • N-11785-5G Dinonyl phthalate 84-76-4 5gm
    • S-11785J4-1ML Dinonyl phthalate Solution 1000ug/ml in Hexane 1mL
    • S-11785J4-5ML Dinonyl phthalate Solution 1000ug/ml in Hexane 5mL
    • N-11603-1G Di-n-propyl phthalate 131-16-8 1gm
    • S-11603B1-1ML Di-n-propyl phthalate Solution 100ug/ml in Acetone 1mL
    • S-11603B1-5ML Di-n-propyl phthalate Solution 100ug/ml in Acetone 5mL
    • N-11798-10G Diphenyl phthalate 84-62-8 10gm
    • N-11798-5G Diphenyl phthalate 84-62-8 5gm
    • S-11798J1-1ML Diphenyl phthalate Solution 100ug/ml in Hexane 1mL
    • S-11798J1-5ML Diphenyl phthalate Solution 100ug/ml in Hexane 5mL
    • NG-16455-1G Diphenyl terephthalate 1539-04-4 1gm
    • N-11824-1G Ditridecyl phthalate 119-06-2 1gm
    • N-11826-10G Diundecyl phthalate 3648-20-2 10gm
    • NG-N90-1G Dodecamethylene diammonium terephthalate 1gm
    • N-10353-10G 2-Ethylhexyl isodecyl phthalate 10gm
    • NG-N100-1G Heptamethylene diammonium terephthalate 1gm
    • NG-N200-1G Hexamethylene diammonium terephthalate 1gm
    • N-12177-10G Hexyl 2-ethylhexyl phthalate 75673-16-4 10gm
    • N-12177-5G Hexyl 2-ethylhexyl phthalate 75673-16-4 5gm
    • S-12177J4-1ML Hexyl 2-ethylhexyl phthalate Solution 1000ug/ml in Hexane 1mL
    • S-12177J4-5ML Hexyl 2-ethylhexyl phthalate Solution 1000ug/ml in Hexane 5mL
    • N-12553-10G Hexyl decyl phthalate 25724-58-7 10gm
    • N-12181-10G Hexyl isodecyl phthalate 10gm
    • NG-12182-10G Hexyl isooctyl phthalate 10gm
    • NG-12235-10G Isobutyl cyclohexyl phthalate 10gm
    • N-12247-10G Isodecyl tridecyl phthalate 10gm
    • N-12252-10G Isohexylbenzyl phthalate 10gm
    • NG-12255-10G Isooctyl benzyl phthalate 10gm
    • NG-12258-10G Isooctyl isodecyl phthalate 10gm
    • NG-12312-10G Lead phthalate (dibasic) 17976-43-1 10gm
    • NG-12312-3G Lead phthalate (dibasic) 17976-43-1 3gm
    • NG-I3915-1G Lithium terephthalate 42596-02-1 1gm
    • N-12490-500MG Monobutyl phthalate 131-70-4 500mg
    • N-12490-5G Monobutyl phthalate 131-70-4 5gm
    • MET-11462A-100MG Monomethyl tetrachloroterephthalate 887-54-7 100mg

    • NG-N350-1G m-Xylylene diammonium iso-phthalate 1gm
    • NG-N360-1G m-Xylylene diammonium tere-phthalate 1gm
    • NG-N240-1G Nonamethylene diammonium terephthalate 1gm
    • N-12586-10G Octyl decyl phthalate 119-07-3 10gm
    • N-12721-10G Octyl isodecyl phthalate 10gm
    • S-13016A1-1ML Phenyl mercuric phthalate Solution 100ug/ml in Acetonitrile 1mL
    • S-13016U1-1ML Phenyl mercuric phthalate Solution 100ug/ml in Toluene 1mL
    • N-13016-100MG Phenylmercuric phthalate 100mg
    • NG-I5745-1G Sodium phthalate 827-27-0 1gm

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