Purospher RP-18 is designed for peak-tailing free chromatography of strongly basic compounds with simple, neutral
mobile phases. Thus, method development time and consequently analyses costs are reduced. Additionally, Purospher®
RP-18 allows the separation of hydrophilic compounds using up to 100% aqueous eluents.
The key for understanding the properties of Purospher® RP-18 lies in the chemistry of the base, high purity silica with
virtually no metal contaminants present. In addition, multi-step chemical modification and deactivation by polymeric
coating and amino shielding of the surface eliminate unpredictable interactions from residual silanols.
This results in
symmetric peak shapes of basic and chelating analytes without the addition of any modifiers to the mobile phase.
Due to the amino endcapping step, Purospher® RP-18 is not suitable for the separation of acidic compounds. The high
chemical stability of Purospher® RP-18 permits the usage of mobile phase conditions at pH 8 for a long period of
time without decline of performance.
Purospher® RP-18 benefits:
Symmetrical paaks for basic, chelating and polar analytes
Fast method development for basic cmpounds.