Wellington Laboratories Devlop Native and Mass-labelled Standards of Bisphenol A
Bisphenol A (BPA) is a high production volume chemical with over 8 billion pounds being produced on a global scale annually. Its use in polycarbonate plastics and epoxy resins has resulted in its incorporation into a vast number of consumer products. Concerns have been raised regarding the leaching of residual BPA from packaging and storage containers into food and beverages due to its reported endocrine disrupting effects.
There have been many studies whose findings have been reported widely. One study links phthalates to increased insulin resistance in children, while another associates bisphenol A (BPA) with high body-mass index (BMI) and expanding waistlines. Both studies appear online Aug. 19 and in the September print issue of Pediatrics.
"There is increasing concern that environmental chemicals might be independent contributors to childhood diseases related to the obesity epidemic," said phthalates study author Dr. Leonardo Trasande, an associate professor of pediatrics and environmental medicine at the NYU School of Medicine. "Our research adds to these growing concerns."
Phthalates are chemicals used to soften and increase the flexibility of plastics and vinyl. They are suspected endocrine disruptors, and manufacturers have discontinued their use in baby products like teething rings and pacifiers.
The study found that insulin resistance in children increased with levels of a phthalate called di-2-ethylhexylphthalate, or DEHP. The association held even after researchers took into account the children's caloric intake, BMI and other risk factors for diabetes.
"There are lab studies suggesting these chemicals can influence how our bodies respond to glucose," Trasande said. "In particular, they are thought to influence genes that regulate release of insulin. There are other potential mechanisms, but that is the main mechanism of concern."
In the other study, researchers Dr. Donna Eng and colleagues at the University of Michigan found that high urinary levels of BPA are associated with increased risk of obesity.
BPA is used to make polycarbonate and epoxy resins for a wide variety of products. For example, aluminum cans use a BPA lining to prevent corrosion. It has been linked to a wide variety of health concerns, and the U.S. Food and Drug Administration has banned its use in sippy cups, baby bottles and infant formula packaging.
The study reviewed data on about 3,300 kids aged 6 to 18, and found that children with high BPA levels tend to have excessive amounts of body fat and unusually expanded waistlines.
Although BPA is the most widely recognised bisphenol on the market, there are a number of analogues that are currently in production to replace it. In fact, recent studies have reported the detection of Bis(4-hydroxyphenyl) sulfone (BPS) and 2,2-Bis(4-hydroxyphenyl) butane (BPB)n in canned food products. Due to the structural similarity between BPA and its analogues, it is believed that this family of compounds will exhibit similar environmental behaviour and toxicity. In order to aid researchers in the detection of BPA and BPA analogues in environmental samples, Wellington Laboratories has produced native and mass-labelled standards of Bisphenol A (BPA and MBPA respectively) as well as seven native bisphenol analogues (BPAF,BPAP,BPB,BPF,BPP,BPS, and BPZ).
Wikipedia: Bisphenol A (BPA) is a man-made carbon-based synthetic compound with the chemical formula (CH3)2C(C6H4OH)2 belonging to the group of diphenylmethane derivatives and bisphenols.
BPA is used to make certain plastics and epoxy resins; it has been in commercial use since 1957. BPA-based plastic is clear and tough, and is used to make a variety of common consumer goods (such as baby and water bottles, sports equipment, and CDs and DVDs) and for industrial purposes, like lining water pipes. Epoxy resins containing BPA are used as coatings on the inside of many food and beverage cans. It is also used in making thermal paper such as that used in sales receipts.
It is part of the bisphenols group of chemical compounds with two hydroxyphenyl functionalities. It is a colorless solid that is soluble in organic solvents, but poorly soluble in water. Bisphenol A has a vapor pressure of 5×10−6 Pa.
BPA exhibits hormone-like properties at high dosage levels that raise concern about its suitability in consumer products and food containers where exposure is orders of magnitude lower. Since 2008, several governments have investigated its safety, which prompted some retailers to withdraw polycarbonate products. A 2010 report from the United States Food and Drug Administration (FDA) identified possible hazards to fetuses, infants, and young children. Since that time numerous studies performed at the National Center for Toxicological Research have been performed that addressed many of those issues.
The United States FDA has removed the use of BPA in baby bottles, sippy cups and infant formula packaging based on market abandonment, not safety. The European Union and Canada have banned BPA use in baby bottles.
Wellington Laboratories products are available to testing institutions worldwide and are supplied by Greyhound Chromatography and Allied Chemicals, Located in Birkenhead, UK. Contact firstname.lastname@example.org for current pricing
In response to ever increasing reports of novel zwitterionic and cationic PFAS contaminants beign found at sites exposed to aqueous film-forming foams (AFFFs), Wellington Laboratories has expanded their PFAS product line to include three zwitterionic AFFF compounds, N-AP-FHxSA, N-TAmP-FHxSA, and N-CMAmP-6:2FOSA (which is commonly referred to as 6:2FTAB in the scientific literature), as well as neutral compouns also detected at impact sites (FHxSA-1 and FBSA-1).
Although the industrial production of polychlorinated napthalenes (PCNs) ceased in the 1970s/1980s, their persistence in the environment as well as their formation during incineratio0n processes has resulted in an ongoing demand for certified reference standards for this group of compounds. In response to customer requests, Wellington Laboratories has expanded their line of native PCNs and prepared mixtures that will aid laboratories in their analysis of these persistant organic pollutants (POPs).
Wellington Laboratories are pleased to introduce a PCN window defining solution/mixture (PCN-WD), two PCN major congeners solutions/mixtures (PCN-HWX and PCN-INC, and a PCN potentially toxic congeners solution/mixture (PCN-TOX). Please see the tables below for the composition of these mixtures.
Also Available from Wellington Laboratories:
Mass-Labelled anti-Dechlorane Plus Ma-DP , Wellington Laboratories Certified Reference Standard
Dechlorane Plus® (DP) is a current use additive polychlorinated flame retardant with a variety of applications including electronic cables and wiring, and plastic building materials. Due to rising concerns regarding the presence of DP, and its related compounds, in environmental samples, Wellington Laboratories has expanded their DP product line to include a mass-labelled anti-DP certified reference standard which will aid in the analysis of this group of compounds.
Further Information about Wellington Products
Perfluorinated Compounds (PFCs) Certified Reference Standards
Wellington Laboratories started to synthesize perfluorinated compounds in 2004 and since then has regularly added new native and mass-labelled standards to their inventory. In the current Wellington Laboratories catalogue, pages 141 - 159 yiou will find individual standards of the following groups of compounds including, in most cases, mass-labelled analogues as well as some useful soultions/mixtures:
PFC-C-CVS Calibration Set and Support Solutions
Perfluoroalkylcarboxylic acide (PFCAs)
Fluorinated Telomer Alcohols (FTOHs)
Fluorinated Telomer Acids (FTAs)
Unsaturanted Telomer Acids (FTUAs)
Perfluoroalkylphosphonic Acids (PFAPAs)
Perfluoroalkylphosphonic Acids (X:XPFPi)
Polyfluorinated Phosphate Esters (PAPs and SAmPAPs)
Fluorinated Telomer Acrylates and Acetates (FTAcrs and FTOAcs)
PFCs are still emerging environmental contaminents and each of the groups of compounds listed above pose unique analytical challenges. In addition, the individual isomers, such as the branched PFOA and PFOS isomers, are being found to have different toxicokinetic and ecokinetic properties. Thus Weliington Laboratories' inventory of PFCs will continue to grow, please visit Wellington's website www.well-labs.com for announcements of new products.
Posters Presented by Wellington Laboratories
Debrominatiobn of PBDEs in DE-83 [TM] Technical mIx By Electrolysis
Attending conferences also allows us to share some of the research that is conducted at our facility in Guelph through poster and oral presentations. A few examples of posters presented by Wellington are provided below for your review.
Dioxin 2019, Kyoto, Japan 25 - 30 August 2019
39th International Symposium on Halogenated Persistent Organic Pollutants
Representatives from Greyhound Chromatography will be attending the Dioxin conference in Kyoto, Japan 25th - 30th August 2019. Paul Massie and Susan Massie will be available on the stand of Platinum sponsors, Wellington Laboratories. The Dioxin conference is an exciting opportunity to meet with our customers, including researchers at the forefront of Dioxin research.
May 10th 2019 Deadline for paper submission
June 30th 2019 Deadline for early bird registration
About Wellington Laboratories
For Over 35 years Wellington Laboratories Inc. has been internationally recognised as a trusted source of high quality reference standard solutions for use in environmental/analytical testing and toxicological research. Wellington Laboratories offers an extensive inventory of individual certified reference standards and solution mixtures of native and mass-labelled halogenated organic compounds including polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, polychlorinated biphenyls, halogenated flame retardants and perfluorinated compounds. Wellington Laboratories also offer a variety of calibration sets and support solutions designed to be used for common regulatory methods or modified in-house methods.
Wellington’s Reference Standards are used mainly in Environmental/analytical testing and toxicological research. Wellington offers an extensive inventory of individual certified reference standards and solution mixtures of native and mass-labelled halogenated organic compounds including polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, polychlorinated biphenyls, halogenated flame retardants and perfluoronated compounds. Wellington also offer a variety of calibration sets and support solutions designed to be used for common regulatory methods of modified in-house methods.
Wellington Laboratories are committed to the distribution of quality products as well as the maintenance of excellent customer service. In fact, in order to provide your customers with the best possible service, Wellington have three ISO certifications (ISO 9001:2008, ISO/IEC 17025:2005, and ISO Guide 34:2009) which cover all aspects of planning, production, testing, distribution, and post-distribution service. These certifications allow Wellington Laboratories to monitor and maintain the highest level of quality and service and also allow their customers to satisfy the requirements of their own ISO certifications.
Wellington’s ISO/IEC 17025:2005 accreditation has been certified by the Canadian Association for Laboratory Accreditation Inc. (CALA) the scope is available for review on the CALA Directory of Accredited Laboratories (http://www.cala.ca).
Similarly, Wellington’s ISO Guide 34:2009 accreditation has been certified by ANSI-ASQ National Accreditation Board (ANAB), the certificate and scope are available on their website (http://anab.org/).
We are able to supply hard copies of any of the ISO certificates for yourself and your customers.
Tel: +44 (0) 151 649 4000